RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
Igf1
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
mus musculus
Detection Methods
In vitro IGF-1 and inhibitor treatments; qRT-PCR; etc.
Target
NA
Pathway
IGF-1/PAKT signaling pathway
PubMed ID
Title
IGF-1 signaling in neonatal hypoxia-induced pulmonary hypertension: Role of epigenetic regulation
Year
2015
Function
"After exposure to hypoxia, IGF-1 signaling is activated in pulmonary endothelial and smooth muscle cells in vitro, and the IGF-1 downstream signal pAKT(S473) is upregulated in lungs of neonatal mice. IGF-1 regulates ET-1 expression in pulmonary endothelial cells and that IGF-1 expression is regulated by histone deacetylases (HDACs). In addition, there is a differential cytosine methylation site in the IGF-1 promoter region in response to neonatal hypoxia. Moreover, inhibition of HDACs with apicidin decreases neonatal hypoxia-induced global DNA methylation levels in lungs and specific cytosine methylation levels around the pulmonary IGF-1 promoter region. Finally, HDAC inhibition with apicidin reduces chronic hypoxia-induced activation of IGF-1/pAKT signaling in lungs and attenuates right ventricular hypertrophy and pulmonary vascular remodeling. Taken together, we conclude that IGF-1, which is epigenetically regulated, is involved in the pathogenesis of pulmonary hypertension in neonatal mice."